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KMID : 0923620080080010001
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Immune Network
2008 Volume.8 No. 1 p.1 ~ p.6
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Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity
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Shota Yamauchi
Takuya Noguchi
Hidenori Ichijo
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Abstract
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Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in
stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of
ASK1 and its involvement in innate immunity.
[Immune Network 2008;8(1):1-6]
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KEYWORD
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ASK1, ROS, thioredoxin, TRAF, TLR4, P2X7 receptor
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